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Carbohydrate Scaffolds for Combinatorial Syntheses That Allow Selective Deprotection of All Four Positions Independent of the Sequence
Author(s) -
Hünger Udo,
Ohnsmann Janina,
Kunz Horst
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352919
Subject(s) - sequence (biology) , carbohydrate , chemistry , scaffold , combinatorial chemistry , stereochemistry , amino acid , side chain , computational biology , biochemistry , computer science , biology , organic chemistry , polymer , database
Irrespective of the sequence , the carbohydrate scaffold 1 as a molecular platform for combinatorial diversification can be selectively deprotected and equipped with side chains, for example amino acids or peptides, in every position (see picture). This allows the flexible arrangement of functional groups and structural elements. PG=protective group.