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Toward an Improved Understanding of the Unusual Reactivity of Pd 0 /Trialkylphosphane Catalysts in Cross‐Couplings of Alkyl Electrophiles: Quantifying the Factors That Determine the Rate of Oxidative Addition
Author(s) -
Hills Ivory D.,
Netherton Matthew R.,
Fu Gregory C.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352858
Subject(s) - electrophile , reactivity (psychology) , catalysis , alkyl , oxidative addition , chemistry , ligand (biochemistry) , catalytic cycle , coupling (piping) , oxidative phosphorylation , combinatorial chemistry , organic chemistry , materials science , biochemistry , medicine , alternative medicine , receptor , pathology , metallurgy
What a difference a ligand makes! The reactivity of Pd 0 /trialkylphosphane complexes is of great interest because of their unusual effectiveness as cross‐coupling catalysts for alkyl electrophiles [Eq. (1)]. This study sheds light on various aspects of the critical oxidative‐addition step of the catalytic cycle.