Premium
Consecutive Double 1,2‐Migration of Two Different Groups in Silyl(dichloromethyl)cuprates
Author(s) -
Kondo Junichi,
Ito Yuki,
Shinokubo Hiroshi,
Oshima Koichiro
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352828
Subject(s) - cyanation , reagent , cuprate , silylation , reactivity (psychology) , chemistry , product (mathematics) , copper , medicinal chemistry , materials science , organic chemistry , mathematics , catalysis , medicine , optoelectronics , geometry , alternative medicine , doping , pathology
Very different reactivity of two types of cuprates : Treatment of a silyldichloromethyllithium compound with a copper reagent prepared from BuMgBr and CuCN gives the product of consecutive dibutylation. On the other hand, Bu 2 CuLi⋅LiCN affords the butylation/cyanation product (see scheme, Si =Ph 2 MeSi).