N ‐Trialkylsilylimines as Coupling Partners for Pd‐Catalyzed CN Bond‐Forming Reactions: One‐Step Synthesis of Imines and Azadienes from Aryl and Alkenyl Bromides | Zendy

Barluenga José | Zendy; Aznar Fernando | Zendy; Valdés Carlos | Zendy

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N ‐Trialkylsilylimines as Coupling Partners for Pd‐Catalyzed CN Bond‐Forming Reactions: One‐Step Synthesis of Imines and Azadienes from Aryl and Alkenyl Bromides

Author(s) -

Barluenga José,

Aznar Fernando,

Valdés Carlos

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200352808

Subject(s) - aryl , moiety , catalysis , chemistry , palladium , coupling reaction , combinatorial chemistry , coupling (piping) , medicinal chemistry , stereochemistry , organic chemistry , materials science , alkyl , metallurgy

A good substitute : Imines, 1‐azadienes, 2‐azadienes, and even 2‐azatrienes are prepared in one step from aryl and alkenyl bromides by palladium‐catalyzed cross‐coupling with N ‐trimethylsilylimines. The reaction introduces N ‐trimethylsilylimines as a synthetic equivalent for the R‐CHN moiety in CN bond‐forming reactions.

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