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Cleavable Linkers for Porous Silicon‐Based Mass Spectrometry
Author(s) -
Meng JunCai,
Averbuj Claudia,
Lewis Warren G.,
Siuzdak Gary,
Finn M. G.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352803
Subject(s) - mass spectrometry , wafer , porous silicon , silicon , porosity , scheme (mathematics) , porous medium , spectrometer , molecule , computer science , chemistry , analytical chemistry (journal) , materials science , nanotechnology , physics , chromatography , organic chemistry , optics , mathematics , mathematical analysis
Dip, wash, and analyze : Molecules can be attached to tailored porous silicon wafers by using Diels–Alder reactions and efficiently detached and detected in the laser pulse of a MALDI mass spectrometer in a positionally encoded manner (see scheme).