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Nontoxic Membrane‐Active Antimicrobial Arylamide Oligomers
Author(s) -
Liu Dahui,
Choi Sungwook,
Chen Bin,
Doerksen Robert J.,
Clements Dylan J.,
Winkler Jeffrey D.,
Klein Michael L.,
DeGrado William F.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352791
Subject(s) - antimicrobial , chemistry , pharmacology , medicine , organic chemistry
Cracking the case : Aryl amide oligomers with amphiphilic secondary structure were designed that attack bacteria by lysing their membranes. A variety of groups were appended to the lead compound to adjust its overall charge, hydrophobicity, and hydrophobic moment. An Arg‐containing oligomer (see figure) was found to have good antimicrobial activity and low toxicity towards human erythrocytes.