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Selective CH Bond Activation by a Supramolecular Host–Guest Assembly
Author(s) -
Leung Dennis H.,
Fiedler Dorothea,
Bergman Robert G.,
Raymond Kenneth N.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352772
Subject(s) - supramolecular chemistry , host (biology) , iridium , tetrahedron , ligand (biochemistry) , denticity , chemistry , stereochemistry , crystallography , crystal structure , biology , organic chemistry , ecology , receptor , biochemistry , catalysis
Interior design : A chiral supramolecular tetrahedral [Ga 4 L 6 ] 12− host (L=bis(bidentate) ligand) is shown to encapsulate a half‐sandwich iridium complex. This host–guest assembly reacts with aldehydes through CH bond activation, which occurs within the host interior. This activation occurs with high size and shape specificity as well as modest diastereoselectivity (d.r. 55:45–70:30) owing to the well‐defined shape of the host cavity.