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Molecularly Imprinted Polymers with Strong Carboxypeptidase A‐Like Activity: Combination of an Amidinium Function with a Zinc‐Ion Binding Site in Transition‐State Imprinted Cavities
Author(s) -
Liu Junqiu,
Wulff Günter
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352770
Subject(s) - molecular imprinting , catalysis , imprinting (psychology) , chemistry , polymer , active site , hydrolysis , combinatorial chemistry , function (biology) , molecularly imprinted polymer , transition state analog , biophysics , nanotechnology , polymer chemistry , materials science , biochemistry , organic chemistry , selectivity , biology , genetics , gene
Impressing models : A novel polymer catalyst shows even higher catalytic activity for the hydrolysis of carbonates than catalytic antibodies prepared for the same purpose. The catalyst was prepared by molecular imprinting with a stable transition state analogue and the introduction of an amidinium function and a Zn 2+ ion in the active site in a defined orientation (see picture).