Premium
Synthesis of Versatile Chiral N,P Ligands Derived from Pyridine and Quinoline
Author(s) -
Drury William J.,
Zimmermann Nicole,
Keenan Martine,
Hayashi Masahiko,
Kaiser Stefan,
Goddard Richard,
Pfaltz Andreas
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352755
Subject(s) - quinoline , pyridine , chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry
Potent transition‐metal complexes for asymmetric catalysis are formed from readily accessible N,P ligands constructed from basic N‐heteroaryl building blocks (see structure). Their simple assembly should not be misconstrued: they posses several handles by which to tune both steric and electronic parameters. The potential of these ligands is demonstrated by the high levels of enantioselection they induce in such divergent processes as asymmetric hydrogenation and the Heck reaction.