Catalytic Generation of Indium Hydride in a Highly Diastereoselective Reductive Aldol Reaction | Zendy

Shibata Ikuya | Zendy; Kato Hirofumi | Zendy; Ishida Tatsuya | Zendy; Yasuda Makoto | Zendy; Baba Akio | Zendy

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Catalytic Generation of Indium Hydride in a Highly Diastereoselective Reductive Aldol Reaction

Author(s) -

Shibata Ikuya,

Kato Hirofumi,

Ishida Tatsuya,

Yasuda Makoto,

Baba Akio

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200352738

Subject(s) - aldol reaction , hydride , catalysis , indium , chemistry , organic chemistry , combinatorial chemistry , hydrogen

A one‐pot synthesis of β‐hydroxyketones has been achieved by the reductive aldol reaction of enones and aldehydes in the presence of Et 3 SiH and a catalytic amount of InBr 3 (see scheme). The reaction is highly diastereoselective and no reduction of the starting aldehydes occurs. This method is superior to conventional reductive aldol reactions in terms of applicability to a wide range of enones and aldehydes.

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