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Combinatorial Synthesis of Functionalized 1,3‐Thiazine Libraries Using a Combined Polymer‐Supported Reagent/Catch‐and‐Release Strategy
Author(s) -
Strohmeier Gernot A.,
Kappe C. Oliver
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352731
Subject(s) - thiazine , reagent , triethylamine , chemistry , combinatorial chemistry , filtration (mathematics) , polymer , dual (grammatical number) , organic chemistry , art , mathematics , statistics , literature
A dual role : The supported sulfonic acid reagent promotes the ring closure of the thiazine products and also binds them in situ as ion pairs (see scheme). The nonbasic by‐products and excess reagents can be removed by filtration and the products subsequently released on treatment with triethylamine (TEA).