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Synthesis and Incorporation of the First Polyketide Synthase Free Intermediate in Monocerin Biosynthesis
Author(s) -
Axford Lorraine C.,
Simpson Thomas J.,
Willis Christine L.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352652
Subject(s) - polyketide synthase , biosynthesis , polyketide , enzyme , atp synthase , biochemistry , stereochemistry , chemistry , biology
Enzyme essential : Feeding studies with Dreschlera ravenelii show that labeled dihydroisocoumarin 1 is metabolized into monocerin ( 2 ) in exceptionally high levels. These results provide evidence for the role of 1 as the first enzyme‐free intermediate in the monocerin biosynthesis pathway and, thus, as the final product of the polyketide synthase (PKS) catalyzed part of the pathway. Compound 1 may therefore be of use in further studies to isolate and sequence the monocerin PKS gene.