Synthesis and Incorporation of the First Polyketide Synthase Free Intermediate in Monocerin Biosynthesis | Zendy

Axford Lorraine C. | Zendy; Simpson Thomas J. | Zendy; Willis Christine L. | Zendy

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Synthesis and Incorporation of the First Polyketide Synthase Free Intermediate in Monocerin Biosynthesis

Author(s) -

Axford Lorraine C.,

Simpson Thomas J.,

Willis Christine L.

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200352652

Subject(s) - polyketide synthase , biosynthesis , polyketide , enzyme , atp synthase , biochemistry , stereochemistry , chemistry , biology

Enzyme essential : Feeding studies with Dreschlera ravenelii show that labeled dihydroisocoumarin 1 is metabolized into monocerin ( 2 ) in exceptionally high levels. These results provide evidence for the role of 1 as the first enzyme‐free intermediate in the monocerin biosynthesis pathway and, thus, as the final product of the polyketide synthase (PKS) catalyzed part of the pathway. Compound 1 may therefore be of use in further studies to isolate and sequence the monocerin PKS gene.

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