Premium
Enantioselective Suzuki Reactions: Catalytic Asymmetric Synthesis of Compounds Containing Quaternary Carbon Centers
Author(s) -
Willis Michael C.,
Powell Luke H. W.,
Claverie Christelle K.,
Watson Simon J.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352648
Subject(s) - enantioselective synthesis , desymmetrization , chemistry , trifluoromethanesulfonate , catalysis , quaternary carbon , organic chemistry , carbon fibers , combinatorial chemistry , materials science , composite number , composite material
Prochiral ditriflates can act as substrates in asymmetric Suzuki couplings by using an enantioselective desymmetrization strategy. The products are obtained with selectivities up to 86 % ee and contain a quaternary carbon center and a synthetically useful vinyl triflate functionality (see scheme).