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Dioxazocinium Ortho Esters: A Class of Highly pH‐Vulnerable Amphiphiles
Author(s) -
By Kolbot,
Nantz Michael H.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352589
Subject(s) - ketene , class (philosophy) , acetal , amphiphile , chemistry , content (measure theory) , combinatorial chemistry , dual (grammatical number) , computer science , stereochemistry , organic chemistry , philosophy , mathematics , artificial intelligence , copolymer , polymer , mathematical analysis , linguistics
Making and breaking lipids : A general synthesis of a new class of ortho ester lipids from a dioxazocinium ketene acetal is disclosed. Both single‐ and dual‐chain analogues were prepared, and the most sensitive of these (see structure) was shown to disassemble at 38 °C within 6 h at pH 5.0.
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