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Identification of Potent Ras Signaling Inhibitors by Pathway‐Selective Phenotype‐Based Screening
Author(s) -
Müller Oliver,
Gourzoulidou Eleni,
Carpintero Mercedes,
Karaguni IoannaMaria,
Langerak Anette,
Herrmann Christian,
Möröy Tarik,
KleinHitpaß Ludger,
Waldmann Herbert
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352587
Subject(s) - sulindac , phenotype , phenotypic screening , signal transduction , computational biology , identification (biology) , high content screening , fidelity , blocking (statistics) , biology , computer science , chemistry , biochemistry , pharmacology , gene , computer network , botany , nonsteroidal , cell , telecommunications
Blocking the path to cancer : Application of efficient strategy for a phenotype‐based screening of compound libraries to a library of sulindac‐derived compounds (see scheme) yielded new inhibitors of the tumor‐relevant Ras signal transduction pathway with high fidelity (as shown by microscopy). The results underline the advantage of using biologically prevalidated compound classes in chemical biology research.