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Synthesis and Biological Evaluation of an Indomethacin Library Reveals a New Class of Angiogenesis‐Related Kinase Inhibitors
Author(s) -
Rosenbaum Claudia,
Baumhof Patrick,
Mazitschek Ralf,
Müller Oliver,
Giannis Athanassios,
Waldmann Herbert
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352582
Subject(s) - angiogenesis , kinase , tyrosine kinase , class (philosophy) , receptor tyrosine kinase , chemistry , pharmacology , cancer research , receptor , biochemistry , biology , computer science , artificial intelligence
Capture and release : Indomethacin has served as a lead compound for the synthesis of a library that revealed a new class of kinase inhibitors. A synthetic approach termed “resin‐capture‐release” was developed (see scheme) that allowed a large library to be synthesized easily. Six of the library compounds were found to be inhibitors of angiogenesis‐related receptor tyrosine kinases.