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Enantioselective, Copper( I )‐Catalyzed Three‐Component Reaction for the Preparation of Propargylamines
Author(s) -
Gommermann Nina,
Koradin Christopher,
Polborn Kurt,
Knochel Paul
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352578
Subject(s) - catalysis , chemistry , enantioselective synthesis , copper , component (thermodynamics) , organic chemistry , reaction conditions , combinatorial chemistry , physics , thermodynamics
The one‐pot reaction of alkynes, aldehydes, and secondary amines in the presence of CuBr/quinap as the catalytic system provides various enantiomerically enriched propargylamines in good yields (up to 99 %) and good selectivities (up to 96 % ee ) [Eq. (1)].
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