Premium
A Concise and Flexible Total Synthesis of (−)‐Diazonamide A
Author(s) -
Burgett Anthony W. G.,
Li Qingyi,
Wei Qi,
Harran Patrick G.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352577
Subject(s) - tripeptide , total synthesis , tyrosine , stereochemistry , chemistry , combinatorial chemistry , biochemistry , amino acid
The remarkable action of an I III species on a tripeptide containing acyclic tyrosine/tryptophan is the key step in a total synthesis of (−)‐diazonamide A. The completed preparation of this new antimitotic is concise, multiply convergent, and amenable to diversification of intermediates.