Premium
Pityriarubins, Biologically Active Bis(indolyl)spirans from Cultures of the Lipophilic Yeast Malassezia furfur
Author(s) -
Irlinger Bernhard,
Krämer HansJoachim,
Mayser Peter,
Steglich Wolfgang
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352549
Subject(s) - malassezia , yeast , indole test , metabolite , tryptophan , biosynthesis , pityriasis , microbiology and biotechnology , biochemistry , biology , chemistry , immunology , enzyme , amino acid
Indole alkaloids , such as pityriarubin A ( 1 ), may be of importance for the pathogenesis of the common skin disease pityriasis versicolor. The metabolite 1 is produced in cultures of the lipophilic yeast Malassezia furfur with tryptophan present as the sole source of nitrogen. The structures of the pityriarubins were derived from spectroscopic investigations, and insight into their biosynthesis was gained by feeding experiments with [1′‐ 13 C]tryptophan.