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Parallel, Double‐Helix DNA Nanostructures Using Interstrand Cross‐Linked Oligonucleotides with Bismaleimide Linkers
Author(s) -
Endo Masayuki,
Majima Tetsuro
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352546
Subject(s) - oligonucleotide , helix (gastropod) , dna , triple helix , double stranded , chemistry , dna origami , flexibility (engineering) , materials science , crystallography , nanotechnology , stereochemistry , biochemistry , biology , mathematics , ecology , statistics , snail
Micrometer‐scale rodlike DNA architectures can be synthesized by one‐step molecular assembly using cross‐linked oligonucleotides with bismaleimide linkers and subsequent DNA ligation (see scheme). Atomic force microscopy studies have shown that the flexibility of the DNA structures in the parallel double‐helix structure is reduced.