Premium
Potential Peptide Carriers: Amphipathic Proline‐Rich Peptides Derived from the N‐Terminal Domain of γ‐Zein
Author(s) -
FernándezCarneado Jimena,
Kogan Marcelo J.,
Castel Susanna,
Giralt Ernest
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352540
Subject(s) - amphiphile , peptide , proline , chemistry , solubility , drug delivery , drug carrier , peptide sequence , sequence (biology) , biochemistry , amino acid , stereochemistry , copolymer , organic chemistry , polymer , gene
Breaking into cells : A new family of peptides based on the amphipathic proline‐rich sequence (VXLPPP) n , where n =1–3 and X=His, Lys, or Arg, has been designed (see picture). Their nonviral origin, absence of toxicity at high concentrations, and high solubility in water make this new series very promising for use in drug delivery.