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Quasi Solvent‐Free Enantioselective Carbonyl‐Ene Reaction with Extremely Low Catalyst Loading
Author(s) -
Yuan Yu,
Zhang Xue,
Ding Kuiling
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352535
Subject(s) - enantioselective synthesis , ene reaction , catalysis , solvent , chemistry , organic chemistry , glyoxylate cycle , mixing (physics) , enzyme , physics , quantum mechanics
Simply mixing the neat substrates and a small amount of the chiral catalyst (0.1–0.01 mol %) under nearly solvent‐free conditions makes the enantioselective carbonyl‐ene reaction of glyoxylate ester with a variety of olefins proceed smoothly to afford the corresponding α‐hydroxy esters in high yields with excellent enantioselectivities [Eq. (1)].
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