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The Palladium‐Catalyzed C–H Activation of Benzylic gem ‐Dialkyl Groups
Author(s) -
Baudoin Olivier,
Herrbach Audrey,
Guéritte Françoise
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352461
Subject(s) - palladium , catalysis , cleavage (geology) , chemistry , medicinal chemistry , bond cleavage , activation energy , polymer chemistry , photochemistry , organic chemistry , materials science , fracture (geology) , composite material
Palladacyclic intermediates effectively lower the high energy barrier to cleavage of a C(sp 3 )H bond. CH activation of benzylic gem ‐dialkyl groups of bromo‐ and iodobenzenes produces olefins and cyclobutabenzenes, respectively, without homocoupling (see scheme).