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Efficient Synthesis of Chiral α‐ and β‐Hydroxy Amides: Application to the Synthesis of ( R )‐Fluoxetine
Author(s) -
Kakei Hiroyuki,
Nemoto Tetsuhiro,
Ohshima Takashi,
Shibasaki Masakatsu
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352431
Subject(s) - regioselectivity , epoxide , reactivity (psychology) , aryl , alkyl , chemistry , stereochemistry , organic chemistry , combinatorial chemistry , catalysis , medicine , alternative medicine , pathology
Four flavors for epoxide openings : The regioselective openings of epoxy amides obtained by asymmetric epoxidation yields all types of aryl‐ and alkyl‐substituted hydroxy amides sometimes counter to the reactivity of the α‐ and β‐positions.