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Development of a Novel Sugar Linkage: 6,6′‐Ether‐Connected Sugars
Author(s) -
Takahashi Hideyo,
Fukuda Toshimitsu,
Mitsuzuka Haruhiko,
Namme Rie,
Miyamoto Hidetoshi,
Ohkura Yasufumi,
Ikegami Shiro
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352388
Subject(s) - ether , sugar , carbohydrate , chemistry , linkage (software) , blood sugar , natural product , stereochemistry , biochemistry , organic chemistry , biology , gene , diabetes mellitus , endocrinology
Unusual sugar dimers : The synthesis of 6,6′‐ether‐connected pyranoses by an acetalization–reduction procedure is described (see scheme). Structure–activity‐relationship studies of these novel carbohydrate dimers suggested that the natural product coyolosa, which has been shown to have a significant effect on fasting blood‐glucose levels, may have a different structure from the one previously reported.