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Highly Antimalaria‐Active Artemisinin Derivatives: Biological Activity Does Not Correlate with Chemical Reactivity
Author(s) -
Haynes Richard K.,
Ho WingYan,
Chan HoWai,
Fugmann Burkhard,
Stetter Jörg,
Croft Simon L.,
Vivas Livia,
Peters Wallace,
Robinson Brian L.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352343
Subject(s) - artemisinin , pharmacology , chemistry , in vivo , biological activity , malaria , combinatorial chemistry , plasmodium falciparum , medicine , biology , in vitro , biochemistry , microbiology and biotechnology , immunology
New leads for antimalarial drugs? 10‐Alkylaminoartemisinin derivatives like that shown display in vivo antimalarial activities greater than those of the parent artemisinin. Previous conclusions regarding the chemical basis for the antimalarial activity of these compounds must be reconsidered.