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CuH‐Catalyzed Asymmetric Conjugate Reductions of Acyclic Enones
Author(s) -
Lipshutz Bruce H.,
Servesko Jeff M.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352313
Subject(s) - conjugate , catalysis , stoichiometry , hydride , chemistry , key (lock) , combinatorial chemistry , enantioselective synthesis , ligand (biochemistry) , computer science , organic chemistry , mathematics , metal , operating system , mathematical analysis , biochemistry , receptor
A powerful new reaction has been developed for the asymmetric 1,4‐reduction of prochiral enones (see scheme). The key ingredients in this exceedingly mild and straightforward procedure are catalytic quantities of CuH, a readily available nonracemic phosphane ligand such as that shown, and inexpensive polymethylhydrosiloxane (PMHS) as the stoichiometric source of hydride.