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Hydrolysis Triggers Oxidation of a trans Diamine Platinum( II ) Anticancer Complex
Author(s) -
Pizarro Ana María,
Munk Vivienne P.,
NavarroRanninger Carmen,
Sadler Peter J.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352303
Subject(s) - platinum , diamine , adduct , aqueous solution , chemistry , hydrolysis , nuclear magnetic resonance spectroscopy , polymer chemistry , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
1 H , 15 N and 195 Pt NMR spectroscopy experiments show that the aqua adducts of a trans diamine platinum( II ) anticancer complex unexpectedly undergo facile oxidation to platinum( IV ) in aqueous solution in air (see picture).