Highly Enantioselective Construction of a Chiral Tertiary Carbon Center by Alkynylation of a Cyclic  N ‐Acyl Ketimine: An Efficient Preparation of HIV Therapeutics | Zendy

Jiang Biao | Zendy; Si YuGui | Zendy

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Highly Enantioselective Construction of a Chiral Tertiary Carbon Center by Alkynylation of a Cyclic N ‐Acyl Ketimine: An Efficient Preparation of HIV Therapeutics

Author(s) -

Jiang Biao,

Si YuGui

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200352301

Subject(s) - alkynylation , enantioselective synthesis , ligand (biochemistry) , chemistry , yield (engineering) , derivative (finance) , combinatorial chemistry , propargyl , carbon fibers , computer science , stereochemistry , catalysis , organic chemistry , physics , algorithm , business , biochemistry , receptor , thermodynamics , finance , composite number

Second‐generation nonnucleoside reverse transcriptase inhibitors can now be efficiently prepared. Alkynylation of the ketimine (see scheme; PMB= p ‐methoxybenzyl) leads to the synthesis of tertiary amines in excellent yield and with high enantioselectivity. The ligand used in the reaction is a derivative of chloramphenicol base.

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