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Chemoselective Reduction of Complex α,β‐Unsaturated Ketones to Allylic Alcohols over Ir‐Metal Particles on β Zeolites
Author(s) -
De bruyn Mario,
Coman Simona,
Bota Roxana,
Parvulescu Vasile I.,
De Vos Dirk E.,
Jacobs Pierre A.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352275
Subject(s) - allylic rearrangement , catalysis , chemistry , zeolite , metal , transformation (genetics) , organic chemistry , ketone , chemoselectivity , biochemistry , gene
The combination of Ir , which has a strong affinity for carbonyl groups, with an acid H‐β zeolite as a support and promotor, provides an effective catalyst for the chemoselective hydrogenation of α,β‐unsaturated aldehydes and ketones to the corresponding allylic alcohols. Steroidal enones are suitable substrates for this transformation (see scheme). R=CH(Me)(CH 2 ) 3 CH(Me) 2 .