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Highly Sensitive Recognition of Substrates of Adrenergic Receptors at the Air/Water Interface
Author(s) -
Molt Oliver,
Schrader Thomas
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352186
Subject(s) - monolayer , receptor , amphiphile , adrenergic receptor , interface (matter) , chemistry , adrenergic , langmuir , computer science , molecular recognition , molecule , biophysics , materials science , biochemistry , aqueous solution , organic chemistry , biology , polymer , copolymer , gibbs isotherm
Almost like the real thing : Amphiphilic properties ensure that an artificial adrenaline receptor can be embedded in lipid monolayers just like the natural example. Here it forms large domains by self‐assembly, which were investigated by Langmuir–Blodgett techniques. Embedded, the macrocyclic receptor is much more sensitive and selective than in solution. Monolayers containing receptor molecules can distinguish between adrenergic receptor substrates with similar structures.