Premium
Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein–Small‐Molecule Interactions
Author(s) -
Kanoh Naoki,
Kumashiro Saori,
Simizu Siro,
Kondoh Yasumitsu,
Hatakeyama Satoru,
Tashiro Hideo,
Osada Hiroyuki
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352164
Subject(s) - small molecule , molecule , photoaffinity labeling , chemistry , natural (archaeology) , combinatorial chemistry , variety (cybernetics) , computer science , nanotechnology , materials science , organic chemistry , binding site , biochemistry , artificial intelligence , archaeology , geography
Library on a glass slide: A variety of small molecules, including complex natural products, are introduced to glass slides using a photoaffinity reaction (see picture). The small molecules retain the inherent ability to interact with the relevant binding proteins. Importantly, this immobilization procedure does not require a specific functional group, and can be applied for use with a diverse small‐molecule library.