Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein–Small‐Molecule Interactions | Zendy

Kanoh Naoki | Zendy; Kumashiro Saori | Zendy; Simizu Siro | Zendy; Kondoh Yasumitsu | Zendy; Hatakeyama Satoru | Zendy; Tashiro Hideo | Zendy; Osada Hiroyuki | Zendy

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Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein–Small‐Molecule Interactions

Author(s) -

Kanoh Naoki,

Kumashiro Saori,

Simizu Siro,

Kondoh Yasumitsu,

Hatakeyama Satoru,

Tashiro Hideo,

Osada Hiroyuki

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200352164

Subject(s) - small molecule , molecule , photoaffinity labeling , chemistry , natural (archaeology) , combinatorial chemistry , variety (cybernetics) , computer science , nanotechnology , materials science , organic chemistry , binding site , biochemistry , artificial intelligence , archaeology , geography

Library on a glass slide: A variety of small molecules, including complex natural products, are introduced to glass slides using a photoaffinity reaction (see picture). The small molecules retain the inherent ability to interact with the relevant binding proteins. Importantly, this immobilization procedure does not require a specific functional group, and can be applied for use with a diverse small‐molecule library.

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