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Supramolecular Adducts between Poly‐ L ‐arginine and [Tm III dotp]: A Route to Sensitivity‐Enhanced Magnetic Resonance Imaging–Chemical Exchange Saturation Transfer Agents
Author(s) -
Aime Silvio,
Delli Castelli Daniela,
Terreno Enzo
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352132
Subject(s) - adduct , chemistry , reagent , diamagnetism , supramolecular chemistry , guanidine , saturation (graph theory) , proton , nuclear magnetic resonance , paramagnetism , crystallography , organic chemistry , crystal structure , physics , mathematics , quantum mechanics , combinatorics , magnetic field
Markedly improved sensitivity is achieved in a contrast agent through formation of a supramolecular adduct between a diamagnetic system endowed with a high number of exchangeable protons (poly‐ L ‐arginine) and a paramagnetic shift reagent ([Tm(Hdotp)] 4− ). The increase in the chemical shift separation between the two exchanging proton pools, induced by the shift reagent, allows irradiation of the mobile guanidine protons of the polymer, thus resulting in a very efficient saturation transfer (see graph).