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Titanium( IV )‐Catalyzed Dynamic Kinetic Asymmetric Transformation of Alcohols, Silyl Ethers, and Acetals under Carbon Allylation
Author(s) -
Braun Manfred,
Kotter Wolfgang
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352128
Subject(s) - silylation , chemistry , catalysis , ether , silyl ether , organic chemistry , titanium , medicinal chemistry , transformation (genetics) , biochemistry , gene
High yields and enantioselectivities are obtained in a dynamic kinetic asymmetric transformation in which the CO bond of alcohols, silyl ethers, and acetals are substituted by a CC bond. For example, the racemic indanyl silyl ether 1 is converted into ( S )‐ 2 in the presence of the chiral Lewis acidic Ti IV complex 3 .