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A Modular Approach to Oxoindolizino Quinolines: Efficient Synthesis of Mappicine Ketone (Nothapodytine B)
Author(s) -
Raolji Gajendra B.,
Garçon Stéphanie,
Greene Andrew E.,
Kanazawa Alice
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352094
Subject(s) - camptothecin , ketone , combinatorial chemistry , chemistry , natural product , stereochemistry , organic chemistry
A general route to oxoindolizino quinolines , such as nothapodytine A, mappicine, camptothecin, and several chemotherapeutic derivatives, is illustrated by the synthesis of the antiviral natural product from Nothapodytes foetida , mappicine ketone (R 1 =R 4 =H, R 2 =CH 3 , R 3 =COC 2 H 5 ). A wide range of new camptothecinoids should now be readily available for biological testing.
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