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Three‐Component Enantioselective Synthesis of Propargylamines through Zr‐Catalyzed Additions of Alkyl Zinc Reagents to Alkynylimines
Author(s) -
Akullian Laura C.,
Snapper Marc L.,
Hoveyda Amir H.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352081
Subject(s) - enantioselective synthesis , reagent , catalysis , alkyl , zinc , component (thermodynamics) , combinatorial chemistry , chemistry , organic chemistry , physics , thermodynamics
Readily available amino acid based chiral ligands are used in a three‐component Zr‐catalyzed enantioselective synthesis of propargylamines (see schemes). The reaction affords important enantiomerically enriched building blocks that are not conveniently accessible by alternative catalytic methods.