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Enantioselective Alkynylation of Aromatic Ketones Catalyzed by Chiral Camphorsulfonamide Ligands
Author(s) -
Lu Gui,
Li Xingshu,
Jia Xian,
Chan Wing Lai,
Chan Albert S. C.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352013
Subject(s) - enantioselective synthesis , alkynylation , catalysis , chemistry , combinatorial chemistry , organic chemistry
The smooth addition of phenylacetylene to aromatic ketones in the presence of catalytic amounts of Cu(OTf) 2 and camphorsulfonamide provides the corresponding tertiary propargylic alcohols in high yields and with up to 97 % ee. This reaction represents a highly enantioselective catalytic addition of dialkynyl zinc reagents to simple ketones.