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A General Method for the Direct α‐Arylation of Nitriles with Aryl Chlorides
Author(s) -
You Jingsong,
Verkade John G.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351954
Subject(s) - aryl , palladium , ligand (biochemistry) , bicyclic molecule , combinatorial chemistry , scheme (mathematics) , chemistry , medicinal chemistry , mathematics , organic chemistry , catalysis , biochemistry , alkyl , receptor , mathematical analysis
The long‐standing challenge of developing a general method for the title methodology is met for a broad range of aryl chlorides through the use of bicyclic P( i BuNCH 2 CH 2 ) 3 N ( 1 ) as a bulky electron‐rich ligand for palladium (see scheme, dba=dibenzylideneacetone).