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Detection of Ligands from a Dynamic Combinatorial Library by X‐ray Crystallography
Author(s) -
Congreve Miles S.,
Davis Deborah J.,
Devine Lindsay,
Granata Cesare,
O′Reilly Marc,
Wyatt Paul G.,
Jhoti Harren
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351951
Subject(s) - x ray , computer science , crystallography , chemistry , combinatorial chemistry , computational biology , biology , physics , quantum mechanics
A dynamic combinatorial library of ligands derived from hydrazines A and isatins B was assembled in the presence of crystals of the target protein, cyclin‐dependent kinase 2 (CDK2). Unambiguous detection of potent ligands, formed as part of the library, was successfully achieved by X‐ray crystallographic analysis.