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6‐Amino‐3‐Pyridinols: Towards Diffusion‐Controlled Chain‐Breaking Antioxidants
Author(s) -
Wijtmans Maikel,
Pratt Derek A.,
Valgimigli Luca,
DiLabio Gino A.,
Pedulli Gian Franco,
Porter Ned A.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351881
Subject(s) - chemistry , radical , dissociation (chemistry) , diffusion , organic chemistry , thermodynamics , physics
The incorporation of nitrogen in the phenolic ring leads to compounds with very low phenolic OH bond dissociation enthalpies, and thus high reactivities towards peroxyl radicals, but which are reasonably stable to direct reactions with air. The 3‐pyridinols 1 and 2 are extremely effective peroxyl‐radical‐trapping chain‐breaking antioxidants.