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Molecular Architecture with Functionalized β‐Peptide Helices
Author(s) -
Brückner Arndt M.,
Chakraborty Pradip,
Gellman Samuel H.,
Diederichsen Ulf
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351871
Subject(s) - peptide , nucleobase , helix (gastropod) , chemistry , amino acid , pairing , combinatorial chemistry , computer science , stereochemistry , crystallography , biochemistry , dna , physics , biology , ecology , snail , superconductivity , quantum mechanics
Specific recognition of β‐peptide helices can be achieved by the incorporation of nucleo‐β‐amino acids in every third position of β‐peptide oligomers. Pairing complexes (see picture) are formed with extraordinary high stabilities in aqueous buffer. A major contribution comes from the high preorganization of the nucleobases by the 14‐helix backbone.