Premium
Total Synthesis of the Proposed Azaspiracid‐1 Structure, Part 1: Construction of the Enantiomerically Pure C1–C20, C21–C27, and C28–C40 Fragments
Author(s) -
Nicolaou K. C.,
Li Yiwei,
Uesaka Noriaki,
Koftis Theocharis V.,
Vyskocil Stepan,
Ling Taotao,
Govindasamy Mugesh,
Qian Wenyuan,
Bernal Federico,
Chen David Y.K.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351825
Subject(s) - enantiomer , trimethylsilyl , chemistry , stereochemistry , medicinal chemistry
As a build‐up to the synthesis of the proposed structure of azaspiracid, both enantiomers of fragments 2, 3 , and 4 were synthesized stereoselectively. Piv=pivaloyl, PFP=pentafluorophenyl, Teoc=2‐(trimethylsilyl)ethoxycarbonyl, TES=triethylsilyl.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom