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The Direct and Enantioselective, One‐Pot, Three‐Component, Cross‐Mannich Reaction of Aldehydes
Author(s) -
Hayashi Yujiro,
Tsuboi Wataru,
Ashimine Itaru,
Urushima Tatsuya,
Shoji Mitsuru,
Sakai Ken
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351813
Subject(s) - enantioselective synthesis , component (thermodynamics) , mannich reaction , chemistry , organic chemistry , combinatorial chemistry , catalysis , physics , thermodynamics
A double‐crossed reaction : The use of proline as an organocatalyst enables a one‐pot, direct, cross‐Mannich reaction to be performed between two different aldehydes and 4‐methoxyaniline in a highly syn ‐diastereo‐ and enantioselective manner (see scheme).

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