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Synthetic Studies on Thiostrepton: Construction of Thiostrepton Analogues with the Thiazoline‐Containing Macrocycle
Author(s) -
Nicolaou K. C.,
Nevalainen Marta,
Zak Mark,
Bulat Stephan,
Bella Marco,
Safina Brian S.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351745
Subject(s) - thiostrepton , thiazoline , diastereomer , natural product , total synthesis , chemistry , stereochemistry , combinatorial chemistry , ribosome , biochemistry , rna , gene
Leading the way : The novel thiostrepton analogue 1 and its 5 S ,6 S diastereomer were synthesized through macrolactamization reactions. Forays towards the total synthesis of the natural product itself should follow a similar strategy.
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