Studies Towards the Synthesis of Azadirachtin: Enantioselective Entry into the Azadirachtin Framework through Cascade Reactions | Zendy

Nicolaou K. C. | Zendy; Roecker A. J. | Zendy; Monenschein Holger | Zendy; Guntupalli Prasuna | Zendy; Follmann Markus | Zendy

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Studies Towards the Synthesis of Azadirachtin: Enantioselective Entry into the Azadirachtin Framework through Cascade Reactions

Author(s) -

Nicolaou K. C.,

Roecker A. J.,

Monenschein Holger,

Guntupalli Prasuna,

Follmann Markus

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200351744

Subject(s) - azadirachtin , enantioselective synthesis , intramolecular force , cascade , chemistry , total synthesis , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , biology , pesticide , chromatography , agronomy

The carbon framework of azadirachtin ( 1 ) has been prepared enantioselectively: The synthesis of compounds 2 a – c follows two novel cascade sequences based on intramolecular radical reactions and acid‐mediated redox chemistry. Such advanced intermediates should allow access to 1 through appropriate functional‐group manipulations.

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