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Highly Branched Oligosaccharides: A General Strategy for the Synthesis of Multiantennary N‐Glycans with a Bisected Motif
Author(s) -
Weiss Harald,
Unverzagt Carlo
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351625
Subject(s) - glycan , motif (music) , chemistry , steric effects , modular design , stereochemistry , computational biology , biochemistry , biology , computer science , glycoprotein , philosophy , programming language , aesthetics
Squeezing in a sugar : A modular building‐block approach was the strategy used in a clever general synthesis of the sterically crowded triantennary N‐glycans bearing an additional bisecting GlcNAc motif (see formula). Key steps include the use of the small trifluoroacetyl protective group and the late introduction of the α1,6‐arm.