Adaptive Behavior of Dynamic Combinatorial Libraries Generated by Assembly of Different Building Blocks | Zendy

Grote Zacharias | Zendy; Scopelliti Rosario | Zendy; Severin Kay | Zendy

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Adaptive Behavior of Dynamic Combinatorial Libraries Generated by Assembly of Different Building Blocks

Author(s) -

Grote Zacharias,

Scopelliti Rosario,

Severin Kay

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200351623

Subject(s) - selection (genetic algorithm) , scheme (mathematics) , composition (language) , computer science , substrate (aquarium) , content (measure theory) , information retrieval , classification scheme , biology , mathematics , artificial intelligence , philosophy , linguistics , ecology , mathematical analysis

Democratic behavior: A strong bias for the amplification of assemblies, the composition of which reflects the overall composition of the library, can be observed in selection processes with dynamic combinatorial libraries. As a consequence, it is not necessarily the assembly with the highest affinity to a given target (for example, a substrate, see scheme) that is amplified the most.

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