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Adaptive Behavior of Dynamic Combinatorial Libraries Generated by Assembly of Different Building Blocks
Author(s) -
Grote Zacharias,
Scopelliti Rosario,
Severin Kay
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351623
Subject(s) - selection (genetic algorithm) , scheme (mathematics) , composition (language) , computer science , substrate (aquarium) , content (measure theory) , information retrieval , classification scheme , biology , mathematics , artificial intelligence , philosophy , linguistics , ecology , mathematical analysis
Democratic behavior: A strong bias for the amplification of assemblies, the composition of which reflects the overall composition of the library, can be observed in selection processes with dynamic combinatorial libraries. As a consequence, it is not necessarily the assembly with the highest affinity to a given target (for example, a substrate, see scheme) that is amplified the most.