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Amplification of Dynamic Chiral Crown Ether Complexes During Cyclic Acetal Formation
Author(s) -
Fuchs Benzion,
Nelson Alshakim,
Star Alexander,
Stoddart J. Fraser,
Vidal Sébastien
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351558
Subject(s) - schematic , yield (engineering) , representation (politics) , crown ether , caesium , acetal , chemistry , ether , ion , combinatorial chemistry , stereochemistry , organic chemistry , physics , thermodynamics , engineering , electronic engineering , politics , political science , law
The dynamic duo : A more than tenfold increase in the yield of the chiral macropolycyclic polyether containing two 2,6‐disubstituted 1,3,5,7‐ cis ‐tetraoxadecalin systems was obtained under thermodynamic conditions from a dynamic combinatorial virtual library with templating cesium ions (>95 % yield, see schematic representation) relative to kinetic syntheses (<8 % yields in their macropolycyclization steps), even when the same template was used.
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