Premium
A Programmable One‐Pot Oligosaccharide Synthesis for Diversifying the Sugar Domains of Natural Products: A Case Study of Vancomycin
Author(s) -
Ritter Thomas K.,
Mong KwokKong T.,
Liu Haitian,
Nakatani Takuji,
Wong ChiHuey
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351534
Subject(s) - vancomycin , glycosylation , oligosaccharide , chemistry , sugar , glycopeptide , antibiotics , combinatorial chemistry , biochemistry , biology , bacteria , staphylococcus aureus , genetics
The notoriously difficult glycosylation of vancomycin was tackled in a one‐pot procedure. A number of oligosaccharides were synthesized and attached to the vancomycin aglycon to create a library of derivatives (see formula) to probe the effect of glycosylation on the antibiotic activity.