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Highly Enantioselective Construction of Quaternary Stereocenters on β‐Keto Esters by Phase‐Transfer Catalytic Asymmetric Alkylation and Michael Reaction
Author(s) -
Ooi Takashi,
Miki Takashi,
Taniguchi Mika,
Shiraishi Misato,
Takeuchi Mifune,
Maruoka Keiji
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351469
Subject(s) - enantioselective synthesis , stereocenter , alkylation , michael reaction , ammonium , quaternary carbon , catalysis , salt (chemistry) , chemistry , phase transfer catalyst , quaternary , organic chemistry , carbon fibers , phase (matter) , combinatorial chemistry , stereochemistry , computer science , biology , algorithm , composite number , paleontology
The designer ammonium salt ( S , S )‐1 catalyzes highly enantioselective phase‐transfer alkylation and Michael reaction of β‐keto esters. This approach provides a reliable route for the asymmetric synthesis of polyfunctionalized compounds having chiral quaternary carbon atoms.